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Profiling of Oestrogen Regulated RNA Binding Protein Landscape Identifies a Role for FXR1 in Endocrine Resistance

GSE276081 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/25 Platform GPL11154
Summary
Dysregulated oestrogen signaling plays a critical role in the development of endocrine resistance and bone metastasis of ER+ breast cancer. Screening of estrogen-regulated RNA-binding proteins by using iTRAQ technology identified that elevated expression of FXR1 is associated with anti-oestrogen resistance. FXR1 belongs to the fragile X mental retardation protein family and participates in RNA splicing, modification, localization, stability, and protein translation. To study the role of FXR1 in breast cancer, we performed RNA-seq assays in FXR1 knockdown and control cells.
Published in
Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4
Shang Y, Cao T, Ma X et al. · Frontiers in cell and developmental biology 2025 · PMID 40196843 · doi:10.3389/fcell.2025.1563353
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Also filed as BioProject PRJNA1154652 and SRA study SRP529707. Searching any of these in the dataset finder brings you back here.

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