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Comparison of the transcriptome of KP4 controls or resistant to Folfirinox after 96h of treatment with Vehicule or Folfirinox

GSE276264 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/31 Platform GPL18573
Summary
FOLFIRINOX induces senescence in pancreatic tumor cells. However, some cells can spontaneously escape this senescence. We wanted to characterize the escape mechanisms from FOLFIRINOX-induced senescence of pancreatic tumor cells. Our in vitro adaptation model to FOLFIRINOX shows that cells that have already escaped 5 treatment cycles become less sensitive to FOLFIRINOX.
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Also filed as BioProject PRJNA1156179 and SRA study SRP530293. Searching any of these in the dataset finder brings you back here.

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