EGR2 O-GlcNAcylation Orchestrates the Development of Protumoral Macrophages to Limit CD8+ T Cell Antitumor Responses.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 27 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8(+) T cell antitumor responsesCell chemical biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276300_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1156578 and SRA study SRP530419. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8496140 WT-TAM-1,EGR2,CUT-Tag
- GSM8496141 WT-TAM-2,EGR2,CUT-Tag
- GSM8496142 WT-TAM-3,EGR2,CUT-Tag
- GSM8496143 KO-TAM-1,EGR2,CUT-Tag
- GSM8496144 KO-TAM-2,EGR2,CUT-Tag
- GSM8496145 KO-TAM-3,EGR2,CUT-Tag
- GSM8496146 WT-TAM-1,H3K27Ac,CUT-Tag
- GSM8496147 WT-TAM-2,H3K27Ac,CUT-Tag
- GSM8496148 WT-TAM-1,H3K4Me1,CUT-Tag
- GSM8496149 WT-TAM-2,H3K4Me1,CUT-Tag
- GSM8496150 WT-TAM-1,EGR2,ATAC
- GSM8496151 WT-TAM-2,EGR2,ATAC
- GSM8496152 WT-TAM-3,EGR2,ATAC
- GSM8496153 KO-TAM-1,EGR2,ATAC
- GSM8496154 KO-TAM-2,EGR2,ATAC
- GSM8496155 KO-TAM-3,EGR2,ATAC
- GSM9013223 WT-TAM,EGR2,ChIP
- GSM9013224 WT-TAM-1,RNA
- GSM9013225 WT-TAM-2,RNA
- GSM9013226 WT-TAM-3,RNA
- GSM9013227 KO-TAM-1,RNA
- GSM9013228 KO-TAM-2,RNA
- GSM9013229 KO-TAM-3,RNA
- GSM9013230 WT_CD45_S1, scRNA
- GSM9013231 WT_CD45_S2, scRNA
- GSM9013232 KO_CD45_S1, scRNA
- GSM9013233 KO_CD45_S2, scRNA
- GSE276107 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity 44 samples shares cd8, orchestrates, antitumor
- GSE299133 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [Hepatocytes] 18 samples shares cd8, orchestrates, antitumor
- GSE262842 Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [ATACseq] 24 samples shares cd8, antitumor
- GSE261642 PLPP1-deficiency-mediated ferroptosis induced by PD-1 signaling impairs antitumor activity of intratumoral CD8+ T cells I 23 samples shares cd8, antitumor
- GSE269347 Daunorubicin-induced T cell remodeling facilitates a high antitumor response to PD-1 blockade therapy by promoting the expansion and effector function of CD8+ prolifeating T cells [scRNA-Seq] 16 samples shares cd8, antitumor
- GSE307388 Immune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones in preclinical models of cancer 12 samples shares cd8, antitumor
- GSE223164 Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor 49 samples shares cd8
- GSE261250 Gfi1 controls the formation of effector CD8+ T cells during chronic infection and cancer 47 samples shares cd8
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.