GEO series
EGR2 O-GlcNAcylation Orchestrates the Development of Protumoral Macrophages to Limit CD8+ T Cell Antitumor Responses.
GSE276300
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
27 samples
2025/06/10
GPL24247
Summary
Tumor associated macrophages (TAMs) exihibit a high capacity to take up glucose, however, how metabolic cues derived from glucose uptake rewire TAMs remains unclear. Here, we report that glucose metabolism-driven protein O-GlcNAcylation shapes the differentiation of protumoral TAMs, thereby accelerating tumor progression. We constructed O-GlcNAc transferase (OGT) conditional-deletion mice to examine MC38 tumor growth.
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Paper (PMID 40499546) ↗
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