GEO series
Hyperploidy is the intermediate state of hepatocyte transforming into ICC
GSE276342
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2026/05/20
GPL24676
Summary
Polyploid cells frequently appear in tumor tissues, but it is not yet conclusively determined whether polyploid cells promote or inhibit tumor development. In this study, we combine two characteristics of hepatocytes—polyploidy and high plasticity—to investigate the role of polyploidy in the transdifferentiation of hepatocytes into precursor cells, as well as its role and mechanism in the further development of intrahepatic cholangiocarcinoma.
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Paper (PMID 40489743) ↗
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