A trigger-inducible split-Csy4 architecture for programmable RNA modulation
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A trigger-inducible split-Csy4 architecture for programmable RNA modulationNucleic acids research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276412_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1157319 and SRA study SRP530536. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8498239 DMSO_Replicate 1 DMSO
- GSM8498240 DMSO_Replicate 2 DMSO
- GSM8498241 DMSO_Replicate 3 DMSO
- GSM8498242 Rapamycin_Replicate 1 Rapamycin
- GSM8498243 Rapamycin_Replicate 2 Rapamycin
- GSM8498244 Rapamycin_Replicate 3 Rapamycin
- GSM8498245 Grazoprevir_Replicate 1 Grazoprevir
- GSM8498246 Grazoprevir_Replicate 2 Grazoprevir
- GSM8498247 Grazoprevir_Replicate 3 Grazoprevir
- GSM8498248 wtCsy4_Replicate 1 wtCsy4
- GSM8498249 wtCsy4_Replicate 2 wtCsy4
- GSM8498250 wtCsy4_Replicate 3 wtCsy4
- GSM8498251 SplitCsy4_DMSO_Replicate 1 SplitCsy4_DMSO
- GSM8498252 SplitCsy4_DMSO_Replicate 2 SplitCsy4_DMSO
- GSM8498253 SplitCsy4_DMSO_Replicate 3 SplitCsy4_DMSO
- GSM8498254 SplitCsy4_Grazoprevir_Replicate 1 SplitCsy4_Grazoprevir
- GSM8498255 SplitCsy4_Grazoprevir_Replicate 2 SplitCsy4_Grazoprevir
- GSM8498256 SplitCsy4_Grazoprevir_Replicate 3 SplitCsy4_Grazoprevir
- GSE290866 Programmable mRNA Therapeutics for Controlled Epigenomic Modulation of Single and Multiplexed Gene Expression in Diverse Diseases (human data) 20 samples shares programmable, modulation
- GSE324454 Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes 128 samples shares architecture
- GSE274546 The Multi-Layered Transcriptional Architecture of Glioblastoma Ecosystems [10X] 121 samples shares architecture
- GSE280041 A long context RNA foundation model for predicting transcriptome architecture 104 samples shares architecture
- GSE322943 Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes [RNA-Seq] 100 samples shares architecture
- GSE330022 Multidimensional Exposure Architecture Shapes Vaping-Associated Transcriptomic Dysregulation in Oral Epithelium 83 samples shares architecture
- GSE296212 LINE-1 locus transcription nucleates oncogenic chromatin architecture [RNA-Seq] 80 samples shares architecture
- GSE245467 Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis 54 samples shares architecture
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.