Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × MMSC_CCT_4.5h vs 3 × MMSC_DMSO_4.5h vs 3 × MMSC_CCT_3.5d vs 3 × MMSC_DMSO_3.5dGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogrammingResearch square · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276459_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1157414 and SRA study SRP530777. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8498851 MMSC_CCT_4.5h_rep1 MMSC_CCT_4.5h
- GSM8498852 MMSC_CCT_4.5h_rep2 MMSC_CCT_4.5h
- GSM8498853 MMSC_CCT_4.5h_rep3 MMSC_CCT_4.5h
- GSM8498854 MMSC_DMSO_4.5h_rep1 MMSC_DMSO_4.5h
- GSM8498855 MMSC_DMSO_4.5h_rep2 MMSC_DMSO_4.5h
- GSM8498856 MMSC_DMSO_4.5h_rep3 MMSC_DMSO_4.5h
- GSM8498857 MMSC_CCT_3.5d_rep1 MMSC_CCT_3.5d
- GSM8498858 MMSC_CCT_3.5d_rep2 MMSC_CCT_3.5d
- GSM8498859 MMSC_CCT_3.5d_rep3 MMSC_CCT_3.5d
- GSM8498860 MMSC_DMSO_3.5d_rep1 MMSC_DMSO_3.5d
- GSM8498861 MMSC_DMSO_3.5d_rep2 MMSC_DMSO_3.5d
- GSM8498862 MMSC_DMSO_3.5d_rep3 MMSC_DMSO_3.5d
- GSE295260 CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation 40 samples shares inhibition, phenotype
- GSE280564 Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype 12 samples shares reprogramming, phenotype
- GSE280280 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer 36 samples shares reprogramming, inhibition
- GSE254366 Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated CRC. 36 samples shares reprogramming, inhibition
- GSE271896 Deep longitudinal immune profiling reveals reprogramming of memory T cells that links to B cell dysregulation with age 868 samples shares reprogramming
- GSE254732 Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects 215 samples shares inhibition
- GSE286918 Metabolic reprogramming and ferroptosis occurring in granulosa cells from patients with diminished ovarian reserve 116 samples shares reprogramming
- GSE232076 In vitro reconstitution of epigenetic reprogramming in the human germ line [RNA-Seq] 89 samples shares reprogramming
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.