RNA sequencing reveals that Taar5 gene knockout in mice up-regulate the striatal expression of genes involved in neuronal connectivity and synaptogenesis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × striatum TAAR5-KO mice, 10 months, animal vs 6 × striatum TAAR5-WT mice, 10 months, animalGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Knocking Out TAAR5: A Pathway to Enhanced Neurogenesis and Dopamine Signaling in the StriatumCells · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276664_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1158475 and SRA study SRP531383. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8503834 striatum TAAR5-KO mice, 10 months, animal 1 striatum TAAR5-KO mice,…
- GSM8503835 striatum TAAR5-KO mice, 10 months, animal 2 striatum TAAR5-KO mice,…
- GSM8503836 striatum TAAR5-KO mice, 10 months, animal 3 striatum TAAR5-KO mice,…
- GSM8503837 striatum TAAR5-KO mice, 10 months, animal 4 striatum TAAR5-KO mice,…
- GSM8503838 striatum TAAR5-KO mice, 10 months, animal 5 striatum TAAR5-KO mice,…
- GSM8503839 striatum TAAR5-KO mice, 10 months, animal 6 striatum TAAR5-KO mice,…
- GSM8503840 striatum TAAR5-WT mice, 10 months, animal 1 striatum TAAR5-WT mice,…
- GSM8503841 striatum TAAR5-WT mice, 10 months, animal 2 striatum TAAR5-WT mice,…
- GSM8503842 striatum TAAR5-WT mice, 10 months, animal 3 striatum TAAR5-WT mice,…
- GSM8503843 striatum TAAR5-WT mice, 10 months, animal 4 striatum TAAR5-WT mice,…
- GSM8503844 striatum TAAR5-WT mice, 10 months, animal 5 striatum TAAR5-WT mice,…
- GSM8503845 striatum TAAR5-WT mice, 10 months, animal 6 striatum TAAR5-WT mice,…
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- GSE285978 Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing 46 samples shares connectivity, neuronal
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- GSE81783 Unexpected role of interferon-g in regulating neuronal connectivity and social behavior 6 samples shares connectivity, neuronal
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- GSE262004 Temporal constraints on enhancer usage and enhancer-promoter connectivity shape the regulation of limb gene transcription [RNA-seq] 99 samples shares connectivity
- GSE283753 Endogenous patterned activity-regulated genes specifically regulate different phases of synaptogenesis in the auditory system 21 samples shares synaptogenesis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.