Dauricine regulates SAT1 to induce ferroptosis and overcome osimertinib resistance in Non-small cell lung cancer
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × PC9-OR, Control vs 3 × PC9-OR, OSI vs 3 × PC9-OR, DAC vs 3 × PC9-OR, DAC+OSIGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1Cancer science · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276807_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1159134 and SRA study SRP531814. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8506085 PC9-OR, Control1 PC9-OR, Control
- GSM8506086 PC9-OR, Control2 PC9-OR, Control
- GSM8506087 PC9-OR, Control3 PC9-OR, Control
- GSM8506088 PC9-OR, OSI1 PC9-OR, OSI
- GSM8506089 PC9-OR, OSI2 PC9-OR, OSI
- GSM8506090 PC9-OR, OSI3 PC9-OR, OSI
- GSM8506091 PC9-OR, DAC1 PC9-OR, DAC
- GSM8506092 PC9-OR, DAC2 PC9-OR, DAC
- GSM8506093 PC9-OR, DAC3 PC9-OR, DAC
- GSM8506094 PC9-OR, DAC+OSI1 PC9-OR, DAC+OSI
- GSM8506095 PC9-OR, DAC+OSI2 PC9-OR, DAC+OSI
- GSM8506096 PC9-OR, DAC+OSI3 PC9-OR, DAC+OSI
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.