Transcriptome analysis the ARPE19 cells with the plasma from cigarette exposure or quit smoking rats
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Naphthalene Metabolites From Long-Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment EpitheliumAging cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276821_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1159168 and SRA study SRP531835. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8506265 Con1M_1 Con1M
- GSM8506266 Con1M_2 Con1M
- GSM8506267 Con1M_3 Con1M
- GSM8506268 CE1M_1 CE1M
- GSM8506269 CE1M_2 CE1M
- GSM8506270 CE1M_3 CE1M
- GSM8506271 CE1MS1M_1 CE1MS1M
- GSM8506272 CE1MS1M_2 CE1MS1M
- GSM8506273 CE1MS1M_3 CE1MS1M
- GSM8506274 Con2M_1 Con2M
- GSM8506275 Con2M_2 Con2M
- GSM8506276 Con2M_3 Con2M
- GSM8506277 CE2M_1 CE2M
- GSM8506278 CE2M_2 CE2M
- GSM8506279 CE2M_3 CE2M
- GSM8506280 CE2MS2M_1 CE2MS2M
- GSM8506281 CE2MS2M_2 CE2MS2M
- GSM8506282 CE2MS2M_3 CE2MS2M
- GSE237252 Transcriptional adaptation of human airway epithelium upon cigarette smoking 77 samples shares cigarette, smoking
- GSE293179 The long-term in vitro co-exposure of polyethylene terephthalate (PET) nanoplastics and cigarette smoke condensate exacerbates the induction of carcinogenic traits 12 samples shares cigarette, exposure
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples shares cigarette, smoking
- GSE338719 Transcriptomic changes in human AC16 cardiomyocytes induced by electronic cigarette aerosol exposure 20 samples shares cigarette, exposure
- GSE274848 Association of smoking with neurocognition, inflammatory and myeloid cell activation profiles in people with HIV on ART 165 samples shares smoking
- GSE308422 Human Blood Exposure to Neutron Radiation at Two Irradiation Facilities 120 samples shares exposure
- GSE286040 Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis 96 samples shares exposure
- GSE252563 Analysis of human liver transcriptome after exposure to okadaic acid 12 samples shares exposure
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.