Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcriptsNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276878_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1159328 and SRA study SRP532070. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8508110 NANOG_AID_0h-1_Nascent-RNA-seq
- GSM8508111 NANOG_AID_0h-2_Nascent-RNA-seq
- GSM8508112 NANOG_AID_2h-1_Nascent-RNA-seq
- GSM8508113 NANOG_AID_2h-2_Nascent-RNA-seq
- GSM8508114 NANOG_AID_4h-1_Nascent-RNA-seq
- GSM8508115 NANOG_AID_4h-2_Nascent-RNA-seq
- GSM8508116 NANOG_AID_8h-1_Nascent-RNA-seq
- GSM8508117 NANOG_AID_8h-2_Nascent-RNA-seq
- GSM8508118 NANOG_AID_24h-1_Nascent-RNA-seq
- GSM8508119 NANOG_AID_24h-2_Nascent-RNA-seq
- GSM8508120 UTP15_AID_0h-1_Nascent-RNA-seq
- GSM8508121 UTP15_AID_0h-2_Nascent-RNA-seq
- GSM8508122 UTP15_AID_4h-1_Nascent-RNA-seq
- GSM8508123 UTP15_AID_4h-2_Nascent-RNA-seq
- GSM8508124 UTP15_AID_24h-1_Nascent-RNA-seq
- GSM8508125 UTP15_AID_24h-2_Nascent-RNA-seq
- GSE276877 Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts [RNA-seq] 14 samples shares nanog, utp15, pluripotency, degradation, transcripts, monitoring, regulating, maintains
- GSE276879 Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts 30 samples shares nanog, utp15, pluripotency, degradation, transcripts, monitoring, regulating, maintains
- GSE284224 Epitranscriptomic program promotes skeletal stem cell quiescence and pluripotency by regulating proteostasis via METTL3-FEM1B-GLI1 axis 44 samples shares pluripotency, regulating
- GSE297660 WDR5 Remodels NANOG Condensates to Drive Transcriptional Programs and Sustain Stem Cell Identity 18 samples shares nanog
- GSE299636 WDR5 Remodels NANOG Condensates to Drive Transcriptional Programs and Sustain Stem Cell Identity [ChIP-seq] 28 samples shares nanog
- GSE199855 shRNA-mediated silencing of candidate pluripotency regulators in mouse epibladst stem cells 798 samples shares pluripotency
- GSE264615 Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos [RNA-seq] 123 samples shares pluripotency
- GSE260522 Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development [RNA-seq] 86 samples shares degradation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.