Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Myeloproliferative neoplasmsThis series is part of our curated briefing on it.
- Samples
- 10 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AMLBlood · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277035_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1160262 and SRA study SRP532329. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 5 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8513046 HEL92.1.7 Control 1 HEL92.1.7 Control
- GSM8513047 HEL92.1.7 Control 2 HEL92.1.7 Control
- GSM8513048 HEL92.1.7 100 nM SY1365 1 HEL92.1.7 100 nM SY1365
- GSM8513049 HEL92.1.7 100 nM SY1365 2 HEL92.1.7 100 nM SY1365
- GSM8513050 HEL92.1.7 100 nM SY5609 1 HEL92.1.7 100 nM SY5609
- GSM8513051 HEL92.1.7 100 nM SY5609 2 HEL92.1.7 100 nM SY5609
- GSM8513052 PD JAK2V617F sAML Control 1 PD JAK2V617F sAML Contr…
- GSM8513053 PD JAK2V617F sAML Control 2 PD JAK2V617F sAML Contr…
- GSM8513054 PD JAK2V617F sAML 100 nM SY5609 1 PD JAK2V617F sAML 100 n…
- GSM8513055 PD JAK2V617F sAML 100 nM SY5609 2 PD JAK2V617F sAML 100 n…
- GSE301154 Preclinical efficacy of tasquinimod-based combinations in advanced myeloproliferative neoplasms (MPN) in blastic phase 32 samples same disease briefing · shares mpn, myeloproliferative, combinations
- GSE277354 Genetic charcterization of myeloproliferative neoplasms (MPN) 402 samples same disease briefing · shares mpn, myeloproliferative
- GSE254423 Single cell RNA sequencing of MPN patients from humans in South Korea 19 samples same disease briefing · shares mpn
- GSE183374 HMGA1 Chromatin Regulators Drive MPN Progression [RNA-Seq] 12 samples same disease briefing · shares mpn
- GSE288386 Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms 37 samples same disease briefing · shares myeloproliferative
- GSE300505 The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN [ChIP-seq] 37 samples same disease briefing · shares mpn
- GSE309082 Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms 29 samples same disease briefing · shares myeloproliferative
- GSE240407 Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A 28 samples same disease briefing · shares mpn
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.