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Lichenoid chronic graft-versus-host skin displays high interferon score with promising effect of IFNAR1 inhibitor on local inflammation

GSE277089 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/01 Platform GPL24676
Summary
Chronic cutaneous graft-versus-host disease (ccGVHD) is a debilitating complication of allogeneic haematopoietic stem cell transplantation, presenting as sclerotic or lichenoid (lGVHD) lesions. Although frequent, the pathogenesis of lGVHD remains mainly unknown. This study aimed to decipher the immunological mechanisms mediating the lichenoid reaction in lGVHD skin. To this end, we performed single-cell RNA-sequencing (scRNA-seq) on lGVHD (n=3) compared with healthy control (HC, n=4) skins and analyzed the distribution and inflammatory signatures of immune cells.
Published in
Lichenoid graft-versus-host disease shows a high interferon score, with IFNAR1 inhibition preventing skin inflammation
Grolleau C, Poisot T, Calugareanu A et al. · Journal of the European Academy of Dermatology and Venereology : JEADV 2025 · PMID 40439472 · doi:10.1111/jdv.20760
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Also filed as BioProject PRJNA1160709 and SRA study SRP532477. Searching any of these in the dataset finder brings you back here.

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