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Gene expression profilling of NEUROG2-mCherry lineage in cerebral organoids

GSE277092 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/19 Platform GPL24014
Summary
To identify and purify NEUROG2-expressing cells and trace their short-term lineage, we engineered two NEUROG2-mCherry knock-in human embryonic stem cell (hESC) lines. Transcriptomic profiling of NEUROG2:mCherry knock-in hESC-derived cerebral organoids revealed an enrichment of neurogenic, oligodendrocyte precursor cell and extracellular matrix-associated gene transcripts in mCherry-high cells. Conversely, only neurogenic gene transcripts were enriched in mCherry-high cells from Neurog2:mCherry knock-in mouse cortices.
Published in
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids
Vasan L, Chinchalongporn V, Saleh F et al. · Development (Cambridge, England) 2025 · PMID 39680368 · doi:10.1242/dev.202703
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Also filed as BioProject PRJNA1160714 and SRA study SRP532481. Searching any of these in the dataset finder brings you back here.

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