GEO series
ICAM1 mRNA Functions Independently of Protein Coding to Inhibit Translation via a dsRNA-ILF2/ILF3 Pathway in Lung Cancer
GSE277238
Homo sapiens
Expression profiling by high throughput sequencing; Other
32 samples
2025/12/29
GPL24676
Summary
This study investigates the role of Intercellular Adhesion Molecule 1 (ICAM1) in lung cancer using RNA-seq and CUT&Tag sequencing. We performed ICAM1 knockout and knockout&knockdown experiments in CALU-1 lung cancer cells to examine changes in gene expression and chromatin accessibility. Our findings provide insights into ICAM1's regulatory mechanisms and its potential as a therapeutic target in lung cancer.
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Paper (PMID 41512856) ↗
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