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ICAM1 mRNA Functions Independently of Protein Coding to Inhibit Translation via a dsRNA-ILF2/ILF3 Pathway in Lung Cancer [CUT&Tag]

GSE277239 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/10/01 Platform GPL24676
Summary
This study investigates the role of Intercellular Adhesion Molecule 1 (ICAM1) in lung cancer using RNA-seq and CUT&Tag sequencing. We performed ICAM1 knockout and knockout&knockdown experiments in CALU-1 lung cancer cells to examine changes in gene expression and chromatin accessibility. Our findings provide insights into ICAM1's regulatory mechanisms and its potential as a therapeutic target in lung cancer.
Published in
ICAM1 mRNA entraps ILF2/ILF3 to inhibit transcription of EIF4E and global protein synthesis
Jiang S, Sun J, Gao Y et al. · Molecular cell 2026 · PMID 41512856 · doi:10.1016/j.molcel.2025.12.017
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Also filed as BioProject PRJNA1161415 and SRA study SRP532821. Searching any of these in the dataset finder brings you back here.

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