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Asymmetric dynamics of GABAergic system and paradoxical responses of GABAergic neurons in piriform seizures

GSE277251 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/10 Platform GPL34290
Summary
The piriform cortex (PC) plays a critical role in epileptogenesis, where an excitation/inhibition imbalance contributes to epilepsy etiology. However, the epileptic dynamics of the GABA system and the precise role of GABAergic neurons within the PC in epilepsy remain unclear. Here, we combined Ca2+ and GABA sensors to investigate the dynamics of Gad2-expressing neurons and GABA levels, and selectively manipulated GABAergic neurons in the PC through chemogenetic inhibition and caspase3-mediated apoptosis targeting Gad2 interneurons. The chronic deficiency of PC Gad2 neurons triggered spontaneous recurrent seizures. These findings uncover the dynamic interplay within PC inhibitory components and elaborate counteractive mechanisms in seizure regulation.
Published in
Asymmetric dynamics of GABAergic system and paradoxical responses of GABAergic neurons in piriform seizures
Tao Y, Zhao Y, Zhong W et al. · Epilepsia 2025 · PMID 39655858 · doi:10.1111/epi.18202
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Also filed as BioProject PRJNA1161575 and SRA study SRP532880. Searching any of these in the dataset finder brings you back here.

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