Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharide
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 6 × hiMG, AβO arm, Control vs 6 × hiMG, AβO arm, AβO vs 6 × hiMG, LPS arm, Control vs 6 × hiMG, LPS arm, LPSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharideScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277259_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1161600 and SRA study SRP532904. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8517282 hiMG, AβO arm, Control1 hiMG, AβO arm, Control
- GSM8517283 hiMG, AβO arm, Control2 hiMG, AβO arm, Control
- GSM8517284 hiMG, AβO arm, Control3 hiMG, AβO arm, Control
- GSM8517285 hiMG, AβO arm, Control4 hiMG, AβO arm, Control
- GSM8517286 hiMG, AβO arm, Control5 hiMG, AβO arm, Control
- GSM8517287 hiMG, AβO arm, Control6 hiMG, AβO arm, Control
- GSM8517288 hiMG, AβO arm, AβO1 hiMG, AβO arm, AβO
- GSM8517289 hiMG, AβO arm, AβO2 hiMG, AβO arm, AβO
- GSM8517290 hiMG, AβO arm, AβO3 hiMG, AβO arm, AβO
- GSM8517291 hiMG, AβO arm, AβO4 hiMG, AβO arm, AβO
- GSM8517292 hiMG, AβO arm, AβO5 hiMG, AβO arm, AβO
- GSM8517293 hiMG, AβO arm, AβO6 hiMG, AβO arm, AβO
- GSM8517294 hiMG, LPS arm, Control1 hiMG, LPS arm, Control
- GSM8517295 hiMG, LPS arm, Control2 hiMG, LPS arm, Control
- GSM8517296 hiMG, LPS arm, Control3 hiMG, LPS arm, Control
- GSM8517297 hiMG, LPS arm, Control4 hiMG, LPS arm, Control
- GSM8517298 hiMG, LPS arm, Control5 hiMG, LPS arm, Control
- GSM8517299 hiMG, LPS arm, Control6 hiMG, LPS arm, Control
- GSM8517300 hiMG, LPS arm, LPS1 hiMG, LPS arm, LPS
- GSM8517301 hiMG, LPS arm, LPS2 hiMG, LPS arm, LPS
- GSM8517302 hiMG, LPS arm, LPS3 hiMG, LPS arm, LPS
- GSM8517303 hiMG, LPS arm, LPS4 hiMG, LPS arm, LPS
- GSM8517304 hiMG, LPS arm, LPS5 hiMG, LPS arm, LPS
- GSM8517305 hiMG, LPS arm, LPS6 hiMG, LPS arm, LPS
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.