Role of Piezo1-mediated mechanotransduction in osteocyte differentiation
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Piezo1-mediated mechanotransduction controls osteocyte maturation and dendrite development via a YAP-CCN-Src signaling axisNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277264_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1161617 and SRA study SRP532915. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 5 replicated groups read from 12 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8517334 WT OCY454 D1 Rep1 WT OCY454 D1
- GSM8517335 WT OCY454 D1 Rep2 WT OCY454 D1
- GSM8517336 WT OCY454 D14 Rep1 WT OCY454 D14
- GSM8517337 WT OCY454 D14 Rep2 WT OCY454 D14
- GSM8517338 WT OCY454 D28 Rep1 WT OCY454 D28
- GSM8517339 WT OCY454 D28 Rep2 WT OCY454 D28
- GSM8517340 Piezo1 KO OCY454 D1 Rep1 Piezo1 KO OCY454 D1
- GSM8517341 Piezo1 KO OCY454 D1 Rep2 Piezo1 KO OCY454 D1
- GSM8517342 Piezo1 KO OCY454 D14 Rep1 Piezo1 KO OCY454 D14
- GSM8517343 Piezo1 KO OCY454 D14 Rep2 Piezo1 KO OCY454 D14
- GSM8517344 Piezo1 KOOCY454 D28 Rep1
- GSM8517345 Piezo1 KO OCY454 D28 Rep2
- GSE334726 Osteocyte Parvalbumin Mediates Mechanotransduction to Attenuate Osteoarthritis 15 samples shares mechanotransduction, osteocyte
- GSE278085 Piezo1-mediated Mechanotransduction Shapes ILC2 Translational Activity, Functions, and Lung Pathogenicity 8 samples shares mechanotransduction, piezo1-mediated
- GSE279338 Piezo1-mediated Mechanotransduction Shapes ILC2 Translational Activity, Functions, and Lung Pathogenicity [II] 4 samples shares mechanotransduction, piezo1-mediated
- GSE54783 The Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3 Hormone [RNA-seq] 30 samples shares osteocyte
- GSE242445 Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner 23 samples shares osteocyte
- GSE154717 Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin [RNA-Seq] 18 samples shares osteocyte
- GSE276370 Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. 15 samples shares osteocyte
- GSE311295 Clip2 as a novel regulator of osteocyte maturation and morphology 14 samples shares osteocyte
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.