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CD28 region-capture HiC of resting and anti-CD3/CD28-stimuated Jurkat cells

GSE277459 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/09/01 Platform GPL20795
Summary
To meticulously explore how local chromatin architecture influences T cell activation, we conducted high-resolution regional capture Hi-C by designing tiling capture probes that span the CD28, CTLA4, and ICOS genes along with their distal regulatory sequences (chr2:204300000-205000000, GRCh37) in both resting and stimulated Jurkat cells.
Published in
Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation
Wang Z, Dong W, Feng X et al. · Science advances 2026 · PMID 41477821 · doi:10.1126/sciadv.ady2539
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Also filed as BioProject PRJNA1162471 and SRA study SRP533370. Searching any of these in the dataset finder brings you back here.

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