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Global landscape mapping of chromatin accessibility in therapy-induced senescent human stromal cells

GSE277466 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/01/14 Platform GPL24676
Summary
We report the application of an improved assay for transposase-accessible chromatin with high-throughput sequencing in profiling changes of chromatin openning status in senescent human stromal cells. By obtaining over four billion bases of sequence from Tn5 transposase-processed chromosome DNAs, we generated genome-wide chromatin-state maps of human primary prostate stromal cells (with a starting cell number of 50,000). This study provides a framework for the application of ATAC-Seq technique towards spatiotemporal chromatin configuration of human stromal cells upon therapy-induced senescence, which is usually caused by typical DDR in damaged cells.
Published in
Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells
Zhang G, Zhang W, Wang C et al. · Aging cell 2026 · PMID 41493135 · doi:10.1111/acel.70366
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Also filed as BioProject PRJNA1162480 and SRA study SRP533371. Searching any of these in the dataset finder brings you back here.

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