GEO series
Effect on adult Human Nasal Organoid transcription of differentiation at 34°C vs. at 37°C vs. at 37°C followed by a 2 day shift to 34°C
GSE277582
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2025/09/22
GPL20301
Summary
Physiological temperature in the human nasal passages peaks at ~34°C, which is lower than internal human body temperature. This experiment explored the effect on the transcriptome of Human Nasal Organoids (HNOs) based on differentiating at 34°C vs. 37°C for 21 days vs. 37°C for 21days followed by a shift to 34°C for 2 additional days. RNAseq was also performed on undifferentiated HNOs.
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Paper (PMID 41025782) ↗
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