GEO series
Changes in peripheral blood mononuclear cells (PBMCs) of 10 patients who underwent continued ADT and stereotactic body radiation therapy (SBRT).
GSE277590
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2025/10/29
GPL24676
Summary
Immunotherapy has been effective in many cancer types, but failed in multiple clinical trials in cancers of the prostate, an organ largely influenced by androgen action. However, the prostate propensity cannot be explained by the immune suppressive activity of androgen receptor (AR) in T cells as reported recently. We use single-cell sequencing to analyze the changes in blood PBMCs of patients who respond good or poorly with ADT and SBRT.
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