GEO series
Cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
GSE277667
Mus musculus
Expression profiling by high throughput sequencing
21 samples
2025/03/19
GPL24247
Summary
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling. Activation of the RAS pathway in the JMML mouse model (MxCre;Ptpn11D61Y) affects apoptosis signaling by regulating BCL-2 family members through oncogenic and microenvironemtal signals, in a cell type-dependent manner. Apoptosis resistance mediated by overexpression of anti-apoptotic and downregulation of pro-apoptotic BCL-2 family members was observed in monocytes and granulocytes.
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Paper (PMID 40057493) ↗
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