Itaconate modulates immune responses via inhibition of peroxiredoxin 5
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × BMDM cells, M, WT vs 3 × BMDM cells, IA, WT vs 3 × BMDM cells, MA, WT vs 3 × BMDM cells, MetSA, WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Itaconate modulates immune responses via inhibition of peroxiredoxin 5Nature metabolism · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277689_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1163360 and SRA study SRP533878. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8527678 BMDM cells, M, WT1 BMDM cells, M, WT
- GSM8527679 BMDM cells, IA, WT1 BMDM cells, IA, WT
- GSM8527680 BMDM cells, MA, WT1 BMDM cells, MA, WT
- GSM8527681 BMDM cells, MetSA, WT1 BMDM cells, MetSA, WT
- GSM8527682 BMDM cells, M, WT2 BMDM cells, M, WT
- GSM8527683 BMDM cells, IA, WT2 BMDM cells, IA, WT
- GSM8527684 BMDM cells, MA, WT2 BMDM cells, MA, WT
- GSM8527685 BMDM cells, MetSA, WT2 BMDM cells, MetSA, WT
- GSM8527686 BMDM cells, M, WT3 BMDM cells, M, WT
- GSM8527687 BMDM cells, IA, WT3 BMDM cells, IA, WT
- GSM8527688 BMDM cells, MA, WT3 BMDM cells, MA, WT
- GSM8527689 BMDM cells, MetSA, WT3 BMDM cells, MetSA, WT
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.