Role of endothelial SOCS3 in the transcriptional response to LPS
RNA-seq (gene expression) · mouse · 45 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 45 samples: 8 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial STING and STAT1 mediate IFN-independent effects of IL-6 in an endotoxemia-induced model of shockThe Journal of clinical investigation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277696_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1163375 and SRA study SRP533896. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 45 samples.
How we read this: 8 replicated groups read from 45 sample titles; they account for 45 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8527756 EC-WT Saline 1 EC-WT Saline
- GSM8527757 EC-WT LPS 1 EC-WT LPS
- GSM8527758 EC-SOCS3iEKO Saline 1 EC-SOCS3iEKO Saline
- GSM8527759 EC-SOCS3iEKO LPS 1 EC-SOCS3iEKO LPS
- GSM8527760 EC-WT LPS 2 EC-WT LPS
- GSM8527761 EC-SOCS3iEKO Saline 2 EC-SOCS3iEKO Saline
- GSM8527762 EC-SOCS3iEKO Saline 3 EC-SOCS3iEKO Saline
- GSM8527763 EC-SOCS3iEKO LPS 2 EC-SOCS3iEKO LPS
- GSM8527764 EC-WT LPS 3 EC-WT LPS
- GSM8527765 EC-SOCS3iEKO LPS 3 EC-SOCS3iEKO LPS
- GSM8527766 EC-SOCS3iEKO LPS 4 EC-SOCS3iEKO LPS
- GSM8527767 EC-SOCS3iEKO LPS 5 EC-SOCS3iEKO LPS
- GSM8527768 EC-WT Saline 2 EC-WT Saline
- GSM8527769 EC-SOCS3iEKO LPS 6 EC-SOCS3iEKO LPS
- GSM8527770 EC-WT LPS 4 EC-WT LPS
- GSM8527771 EC-SOCS3iEKO Saline 4 EC-SOCS3iEKO Saline
- GSM8527772 EC-WT LPS 5 EC-WT LPS
- GSM8527773 EC-WT LPS 6 EC-WT LPS
- GSM8527774 EC-WT Saline 3 EC-WT Saline
- GSM8527775 EC-WT Saline 4 EC-WT Saline
- GSM8527776 EC-WT LPS 7 EC-WT LPS
- GSM8527777 EC-WT Saline 5 EC-WT Saline
- GSM8527778 total-WT Saline 1 total-WT Saline
- GSM8527779 total-WT LPS 1 total-WT LPS
- GSM8527780 total-SOCS3iEKO Saline 1 total-SOCS3iEKO Saline
- GSM8527781 total-SOCS3iEKO LPS 1 total-SOCS3iEKO LPS
- GSM8527782 total-WT LPS 2 total-WT LPS
- GSM8527783 total-SOCS3iEKO Saline total-SOCS3iEKO Saline
- GSM8527784 total-SOCS3iEKO Saline 2 total-SOCS3iEKO Saline
- GSM8527785 total-SOCS3iEKO Saline 3 total-SOCS3iEKO Saline
- GSM8527786 total-SOCS3iEKO LPS 2 total-SOCS3iEKO LPS
- GSM8527787 total-WT LPS 3 total-WT LPS
- GSM8527788 total-SOCS3iEKO LPS 3 total-SOCS3iEKO LPS
- GSM8527789 total-SOCS3iEKO LPS 4 total-SOCS3iEKO LPS
- GSM8527790 total-SOCS3iEKO LPS 5 total-SOCS3iEKO LPS
- GSM8527791 total-WT Saline 2 total-WT Saline
- GSM8527792 total-SOCS3iEKO LPS 6 total-SOCS3iEKO LPS
- GSM8527793 total-WT LPS 4 total-WT LPS
- GSM8527794 total-SOCS3iEKO Saline 4 total-SOCS3iEKO Saline
- GSM8527795 total-WT LPS 5 total-WT LPS
+ 5 more — browse all 45 samples with per-sample file links →
- GSE201128 The response to lipopolysaccharide (LPS) of bone marrow derived macrophages treated with oxysterol binding protein (OSBP) inhibitors 30 samples shares lps
- GSE332798 Transcriptomic profiling of morphine and LPS exposure across mouse brain regions 208 samples shares lps
- GSE254687 PARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation 19 samples shares lps
- GSE250279 25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of LPS-induced neuroinflammation. 40 samples shares lps
- GSE181641 Oxygen-dependent changes of gene expression in BMDM after LPS treatment 36 samples shares lps
- GSE290810 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits [FACS_SpinalCord_Microglia & LPS_Brain_SpinalCord] 35 samples shares lps
- GSE300619 STAT1-dependent expression in kidney endothelium from mice challenged with LPS 32 samples shares lps
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares lps
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.