← BioTransfer GEO Dataset Finder
GEO series

Phf23 regulates embryonic neurogenesis by increasing the level of H3K27ac of Tcf4 [CUT&Tag]

GSE277736 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/06/30 Platform GPL24247
Summary
Epigenetic regulation is an important cell fate modality that is ubiquitous in neural development and plays an important role in both the fate determination and differentiation of neural stem cells (NSCs). The epigenetic regulator Phf23 is widely expressed in different human tissues and is involved in various biological processes, but its functional role in development has rarely been reported. Here, we found that Phf23 is an important epigenetic regulator that maintains embryonic neurogenesis in mice, and its absence leads to inhibition of the acetylation level of H3K27ac through the function of Hdac2, resulting in the blockage of embryonic NSCs differentiation at embryonic day 13.5 (E13.5). Tcf4, a transcription factor closely associated with neurogenesis, is a key downstream target gene of Phf23 in regulating embryonic neurogenesis, which may provide insights into the neuromodulatory network of the brain and the diagnosis and treatment of clinically relevant diseases.
Published in
The Epigenetic Reader PHF23 Is Required for Embryonic Neurogenesis
Wen Y, He P, Huang Z et al. · The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 · PMID 40447447 · doi:10.1523/JNEUROSCI.2090-24.2025
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE277736_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1163697 and SRA study SRP534002. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.