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DDX6 undergoes phase separation to modulate metabolic plasticity and drug resistance in AML

GSE277986 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/27 Platform GPL11154
Summary
DDX6 is a member of the DEAD-box helicase and it is highly expressed in acute myeloid leukemia (AML). The Knockout (KO) of DDX6 in AML cells significantly suppressed their growth, reduced their mitochondrial oxidative phosphorylation (OXPHOS) in vitro, and substantially delayed leukemogenesis in vivo. To delineate the molecular mechanism through which DDX6 exerts its biological functions in AML, we conducted transcriptome-wide RNA sequencing with Mono-mac-6 AML cells following DDX6 KO.
Published in
DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance
Bi H, Li W, Ren L et al. · Nature communications 2025 · PMID 41330929 · doi:10.1038/s41467-025-66966-4
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Also filed as BioProject PRJNA1165158 and SRA study SRP534667. Searching any of these in the dataset finder brings you back here.

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