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Targeting VRK2 Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma by Reducing Direct Phosphorylation and Stability of MYC,CUT-TAG sequencing for MYC in hepatocellular carcinoma cells

GSE277990 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/22 Platform GPL24676
Summary
VRK2–MYC axis, a transcription-dependent regulatory axis, could be a prognostic indicator and potential therapeutic target in liver cancer.
Published in
VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization
Su C, Liao Z, Mo J et al. · Nature communications 2025 · PMID 41073389 · doi:10.1038/s41467-025-64079-6
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Also filed as BioProject PRJNA1165168 and SRA study SRP534672. Searching any of these in the dataset finder brings you back here.

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