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Transcriptomic analysis of NAFLD model cells with the co-administration of pseudo-natural flavonol and copper

GSE278008 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/31 Platform GPL34284
Summary
Copper deficiency is closely associated with non-alcoholic fatty liver disease (NAFLD). We developed pseudo-natural flavonol (HQF) as novel ionophore for rapid intracellular copper delivery. The co-administration of HQF and copper has synergistic effects in restraining lipid droplet formation with unknown mechanism. Here, hepatic HepG2 cells were treated with palmitic acid (PA) to construct a NAFLD cell model, which was used to investigate the biological effects of HQF-mediated copper delivery on NAFLD intervention.
Published in
Pseudonatural Flavonols as Novel Copper Ionophores for NAFLD Intervention via Synergistic Copper Delivery and Flavonoid Activity
Jiang J, Chen G, Zhang W et al. · Journal of medicinal chemistry 2025 · PMID 40080431 · doi:10.1021/acs.jmedchem.4c02927
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Also filed as BioProject PRJNA1165211 and SRA study SRP534807. Searching any of these in the dataset finder brings you back here.

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