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ACSS2-coupled KAT2A regulates histone H3 lactylation in gene promoter regions and gene expression

GSE278139 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/10/01 Platform GPL24676
Summary
We report EGFR activation induces ERK-mediated S267 phosphorylation of acetyl-CoA synthetase 2 (ACSS2) and its subsequent nuclear translocation and complex formation with lysine acetyltransferase 2A (KAT2A).Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to expression of Wnt/β-catenin, NFκB, and PD-L1, and brain tumor growth and immune evasion.
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Also filed as BioProject PRJNA1165757 and SRA study SRP535017. Searching any of these in the dataset finder brings you back here.

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