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Gene expression profiling of murine SCLC tumor subpopulations with high and low autophagic flux

GSE278235 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/02 Platform GPL24247
Summary
Small cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, driving its aggressive progression and resistance to therapy. Understanding the underlying mechanisms of these features is crucial for improving treatment outcomes. Autophagy, a conserved cellular process, is involved in many cancers, but its role in SCLC remains unclear. Using a genetically engineered mouse model (Rb1fl/fl;Trp53fl/fl;GFP-LC3-RFP-LC3△G), we tracked autophagic flux in vivo to assess its effects on SCLC biology. Tumor subpopulations with high autophagic flux exhibited increased proliferation, enhanced metastatic potential, and neuroendocrine (NE) characteristics, whereas subpopulations with low autophagic flux exhibited more immune-related signals and non-NE traits.
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Direct links to NCBI, no account and no request form: the whole study as GSE278235_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1166151 and SRA study SRP535404. Searching any of these in the dataset finder brings you back here.

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