SF3B1 K700E Mutation Induces Genome-Wide Enhancement of Transcriptional Pause Release in ES Cells [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genesPloS one · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278363_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1166879 and SRA study SRP535574. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE262021 Synthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-Seq 2] 12 samples shares sf3b1, mutation, rna-seq
- GSE304350 Distinct and convergent effects of SF3B1 mutations in human breast cancer 30 samples shares sf3b1, mutation
- GSE268355 Cancer-associated SF3B1 Mutations Inhibit mRNA Nuclear Export by Disrupting SF3B1–THOC5 Interactions 12 samples shares sf3b1, mutation
- GSE231387 Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis 12 samples shares sf3b1, mutation
- GSE263299 Mis-splicing of mitotic regulators sensitizes SF3B1-mutated human HSCs to CHK1 inhibition [RNA-seq] 10 samples shares sf3b1, rna-seq
- GSE281303 Multimodal Genome-wide Survey of Progressing and Non-progressing Breast Ductal Carcinoma In-Situ [RNA-seq] 123 samples shares genome-wide, rna-seq
- GSE279032 Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing [RNA-seq] 60 samples shares genome-wide, rna-seq
- GSE271456 Locus-specific and genome-wide analysis of adaptations to hypoxia in iPSC-derived endothelium from a population adapted to high altitude [RNA-Seq] 20 samples shares genome-wide, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.