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IGFBP-7 transforms hepatic stellate cells into an HCC-promoting phenotype in MASLD.

GSE278593 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/20 Platform GPL24676
Summary
Hepatic fibrosis is the strongest contributor to hepatocarcinogenesis in metabolic dysfunction-associated steatotic liver disease (MASLD); however, the underlying mechanisms have yet to be fully elucidated. In 94 human MASLD biopsy samples, artificial intelligence-based morphological phenotyping of hepatic fiber and multi-omics analyses revealed that insulin growth factor-binding protein 7 (IGFBP-7) secreted from senescent periportal endothelial cells might transform stellate cells into a hepatocarcinogenesis-promoting phenotype. To test the effect of IGFBP-7 on HSC, a hepatic stellate cell line, LX-2, was cultured with recombinant IGFBP-7 (100ng/mL), resulting in their transformation to a more activated form than the control.
Published in
AI-based phenotyping of hepatic fiber morphology to inform molecular alterations in metabolic dysfunction-associated steatotic liver disease
Fujiwara N, Matsushita Y, Tempaku M et al. · Hepatology (Baltimore, Md.) 2026 · PMID 40262132 · doi:10.1097/HEP.0000000000001360
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Also filed as BioProject PRJNA1168053 and SRA study SRP536188. Searching any of these in the dataset finder brings you back here.

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