Growth signaling promotes H2A.Z deposition by SRCAP to sustain somatic tissue regeneration [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 30 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 30 samples: 25 distinct titles, 5 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Skin Epidermal Progenitor Maintenance by the SRCAP-H2A.Z Axis Downstream to Extracellular Signal-Regulated Kinase and mTOR SignalingThe Journal of investigative dermatology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278642_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1168137 and SRA study SRP536263. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 30 sample titles: 25 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8551815 progenitor A
- GSM8551816 progenitor B
- GSM8551817 Differentiated, d4 A
- GSM8551818 Differentiated, d4 B
- GSM8551819 Control 1
- GSM8551820 Control 2
- GSM8551821 EP400 shRNA2
- GSM8551822 EP400 shRNA4
- GSM8551823 SRCAP shRNA3
- GSM8551824 SRCAP shRNA5
- GSM8551825 DMSO A
- GSM8551826 DMSO B
- GSM8551827 EGFRi A
- GSM8551828 EGFRi B
- GSM8551829 MEKi A
- GSM8551830 MEKi B
- GSM8551831 ERKi A
- GSM8551832 ERKi B
- GSM8551833 DMSO X
- GSM8551834 DMSO Y
- GSM8551835 PI3Ki X
- GSM8551836 PI3Ki Y
- GSM8551837 AKTi X
- GSM8551838 AKTi Y
- GSM8551839 mTORi X
- GSM8551840 mTORi Y
- GSM8801185 DF H2A.Z, control 1
- GSM8801186 DF H2A.Z, control 2
- GSM8801191 DF H2A.Z, SRCAP shRNA 1
- GSM8801192 DF H2A.Z, SRCAP shRNA 3
- GSE278641 Growth signaling promotes H2A.Z deposition by SRCAP to sustain somatic tissue regeneration [RNA-Seq] 42 samples shares srcap, h2a, regeneration, deposition, promotes, sustain, somatic
- GSE292167 SRCAP mutation promotes cutatneous squamous cell carcinoma invasion [ChIP-Seq] 8 samples shares srcap, promotes, chip-seq
- GSE280574 mChIP-seq for high-throughput epigenomic profiling reveals a decoupling of H2A.Z and H3K4me3 in cancer 576 samples shares h2a, chip-seq
- GSE310167 Embryonic stem cell factors DPPA2/4 amplify active H3K4me3-H2AK119ub chromatin domains in non-small cell lung cancer (ChIP-seq) 54 samples shares h2a, chip-seq
- GSE229396 PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ChIP-Seq) 26 samples shares h2a, chip-seq
- GSE232112 Roles of H2A.Z histone variant isoforms during enterocyte-like differentiation process (ChIP-Seq) 17 samples shares h2a, chip-seq
- GSE303932 Regional Conservation and Transcriptional Regulation of Tumor-Associated Genes by macroH2A1 Deposition in Mammalian Cells 12 samples shares h2a, deposition
- GSE289711 Regulation of Epstein–Barr Virus latency by histone variant H2A.Z [ChIP-seq] 10 samples shares h2a, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.