Targeting COPA to enhance erdafitinib sensitivity in FGFR-altered bladder cancer
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Bladder cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder CancerAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278672_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1168176 and SRA study SRP536310. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8552746 WT1_DMSO
- GSM8552747 WT2_DMSO
- GSM8552748 WT3_DMSO
- GSM8552749 WT1_Erdafitinib
- GSM8552750 WT2_Erdafitinib
- GSM8552751 WT3_Erdafitinib
- GSM8552752 KO1_DMSO
- GSM8552753 KO2_DMSO
- GSM8552754 KO3_DMSO
- GSM8552755 KO1_Erdafitinib
- GSM8552756 KO2_Erdafitinib
- GSM8552757 KO3_Erdafitinib
- GSE214886 Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer 12 samples same disease briefing · shares sensitivity, bladder
- GSE211924 UCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5. 9 samples same disease briefing · shares targeting, bladder
- GSE181389 Transcriptome profiling of HOXA13 and HOXB13 expression knockdown in bladder cancer cell lines. 59 samples same disease briefing · shares bladder
- GSE193755 Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 12 samples same disease briefing · shares bladder
- GSE172359 Combination of urine exosomal mRNAs and lncRNAs as novel diagnostic biomarkers for bladder cancer 6 samples same disease briefing · shares bladder
- GSE182310 Transcriptome sequence of Human bladder cancer cell line 6 samples same disease briefing · shares bladder
- GSE193753 Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy 6 samples same disease briefing · shares bladder
- GSE193754 Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - untreated 6 samples same disease briefing · shares bladder
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.