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Steroid Receptor Coactivator-2 Controls Human Extravillous Trophoblast Cell Proliferation, Migration, and Invasion

GSE278677 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/29 Platform GPL24676
Summary
Abnormal placentation is a fundamental cause of pregnancy complications including preeclampsia, miscarriage, and intrauterine growth restriction. Proliferation, differentiation, migration, and invasion are key properties of trophoblast cells that regulate trophoblast functions. Imbalance of these cellular processes is linked to placental pathologies. Using HTR-8/SVneo immortalized human trophoblast cells, we demonstrate that steroid receptor coactivator-2 (SRC-2), a transcriptional regulator of nuclear receptors, is essential for extravillous trophoblast cell proliferation, migration, and invasion. Genome-wide transcriptomics identified an SRC-2–dependent transcriptome in HTR-8/SVneo cells that includes a diverse spectrum of proteins involved in placental tissue development and function. To emphasize the utility of this transcriptomics data set, we demonstrate that WNT family member 9A (WNT9A) is not only a molecular target of SRC-2 but also crucial for maintaining many of the cellular properties of human extravillous trophoblast cells.
Published in
Human Extravillous Trophoblasts Require SRC-2 for Sustained Viability, Migration, and Invasion
Maurya VK, Popli P, Nikolai BC et al. · Cells 2025 · PMID 40643542 · doi:10.3390/cells14131024
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Also filed as BioProject PRJNA1168193 and SRA study SRP536321. Searching any of these in the dataset finder brings you back here.

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