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Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model

GSE278799 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2025/10/31 Platform GPL24676
Summary
Advanced glycation end-products (AGEs) accumulate in brain tissue with as we age, co-localizing with amyloid β and tau in the brains of elderly and Alzheimer’s disease patients. However, the link between increased AGE levels, aging, and neurodegeneration remains unclear. To explore the effect and mechanism of AGEs on the brain, we developed a neurovascular (NV) model that reflects features of an aged brain by integrating an AGE-anchored matrix. Notably, we discovered that targeting AGE and its receptor could attenuate AGE-mediated neurodysfunction through the histone-modifying enzyme, KMT2A, in neurons within an aged NV model.
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Also filed as BioProject PRJNA1168950 and SRA study SRP536627. Searching any of these in the dataset finder brings you back here.

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