GEO series
RNA-seq analysis using A549 cells with FXR knockdown and control A549 cells with or without ionizing radiation treatment.
GSE278872
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/10/31
GPL11154
Summary
In this study, we explored the role of FXR in the response to ionizing radiation (IR) in A549 human lung cancer cells. FXR was stably knocked down in A549 cells using shRNA, and four experimental groups were established: control A549 cells (non-irradiated), control A549 cells (irradiated), FXR knockdown A549 cells (non-irradiated), and FXR knockdown A549 cells (irradiated). RNA sequencing (RNA-seq) was performed to identify gene expression changes associated with FXR knockdown and irradiation. This dataset provides insights into the molecular mechanisms by which FXR influences the cellular response to radiation and its potential impact on cancer therapy.
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