Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
RNA-seq (gene expression) · C. elegans · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Caenorhabditis elegans (C. elegans)
- Samples
- 32 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across SpeciesAging cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278873_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1169340 and SRA study SRP536780. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 8 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8556360 0% top2 RNAi_1 0% top2 RNAi
- GSM8556361 0% top2 RNAi_2 0% top2 RNAi
- GSM8556362 0% top2 RNAi_3 0% top2 RNAi
- GSM8556363 0% top2 RNAi_4 0% top2 RNAi
- GSM8556364 50% top2 RNAi_1 50% top2 RNAi
- GSM8556365 50% top2 RNAi_2 50% top2 RNAi
- GSM8556366 50% top2 RNAi_3 50% top2 RNAi
- GSM8556367 50% top2 RNAi_4 50% top2 RNAi
- GSM8556368 Ske_gLacz_1 Ske_gLacz
- GSM8556369 Ske_gLacz_2 Ske_gLacz
- GSM8556370 Ske_gLacz_3 Ske_gLacz
- GSM8556371 Ske_gLacz_4 Ske_gLacz
- GSM8556372 Ske_gtop2b_1 Ske_gtop2b
- GSM8556373 Ske_gtop2b_2 Ske_gtop2b
- GSM8556374 Ske_gtop2b_3 Ske_gtop2b
- GSM8556375 Ske_gtop2b_4 Ske_gtop2b
- GSM8556376 Lung_gLacz_1 Lung_gLacz
- GSM8556377 Lung_gLacz_2 Lung_gLacz
- GSM8556378 Lung_gLacz_3 Lung_gLacz
- GSM8556379 Lung_gLacz_4 Lung_gLacz
- GSM8556380 Lung_gtop2b_1 Lung_gtop2b
- GSM8556381 Lung_gtop2b_2 Lung_gtop2b
- GSM8556382 Lung_gtop2b_3 Lung_gtop2b
- GSM8556383 Lung_gtop2b_4 Lung_gtop2b
- GSM8556384 Kidney_gLacz_1 Kidney_gLacz
- GSM8556385 Kidney_gLacz_2 Kidney_gLacz
- GSM8556386 Kidney_gLacz_3 Kidney_gLacz
- GSM8556387 Kidney_gLacz_4 Kidney_gLacz
- GSM8556388 Kidney_gtop2b_1 Kidney_gtop2b
- GSM8556389 Kidney_gtop2b_2 Kidney_gtop2b
- GSM8556390 Kidney_gtop2b_3 Kidney_gtop2b
- GSM8556391 Kidney_gtop2b_4 Kidney_gtop2b
No close match found for this topic, so these are simply the most-viewed datasets of the same kind.
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.