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Gene expression changes induced by HA-PRCC-TFE3 in HK-2 cells

GSE278984 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/07 Platform GPL18573
Summary
PRCC-TFE3 is an oncogenic chimeric transcription factor identified in human TFE3-rearranged renal cell carcinoma. To analyze gene expression changes driven by PRCC-TFE3, we generated and utilized an HA-tagged PRCC-TFE3-inducible HK-2 cell line, which expresses HA-tagged PRCC-TFE3 in a doxycycline-dependent manner. Cells were cultured with or without doxycycline, and comprehensive gene expression analysis was conducted using RNA-seq.
Published in
ARID2 Deficiency Enhances Tumor Progression via ERBB3 Signaling in TFE3-Rearranged Renal Cell Carcinoma
Tang J, Funasaki S, Nishizawa H et al. · Current issues in molecular biology 2024 · PMID 39727945 · doi:10.3390/cimb46120817
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Also filed as BioProject PRJNA1169872 and SRA study SRP536984. Searching any of these in the dataset finder brings you back here.

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