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Gene expression changes induced by ARID2 knockout in UOK124 cells.

GSE279136 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/07 Platform GPL18573
Summary
TFE3-rearranged Renal Cell Carcinoma (TFE3-RCC) is an aggressive RCC subtype characterized by Xp11.2 rearrangements, resulting in TFE3 fusion proteins with oncogenic potential. To investigate the role of ARID2, a component of the SWI/SNF chromatin remodeling complex, in TFE3-RCC, we knocked out the ARID2 gene in a TFE3-RCC cell line, UOK124, which is derived from human TFE3-RCC with the PRCC-TFE3 fusion gene. UOK124 parental cells (UOK124-WT) and UOK124-ARID2_KO cells were cultured, and comprehensive gene expression analysis was performed using RNA-seq.
Published in
ARID2 Deficiency Enhances Tumor Progression via ERBB3 Signaling in TFE3-Rearranged Renal Cell Carcinoma
Tang J, Funasaki S, Nishizawa H et al. · Current issues in molecular biology 2024 · PMID 39727945 · doi:10.3390/cimb46120817
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Also filed as BioProject PRJNA1170958 and SRA study SRP537607. Searching any of these in the dataset finder brings you back here.

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