Tp53 and Tet2 mutations cooperatively transform progenitors (RNA-Seq)
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environmentThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279386_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1172353 and SRA study SRP538314. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8568404 BM.WT.LSK.3.BAM
- GSM8568405 BM.WT.LSK.1.BAM
- GSM8568406 BM.TP53.LSK.2.BAM
- GSM8568407 BM.TP53.LSK.1.BAM
- GSM8568408 BM.TET2.LSK.1.BAM
- GSM8568409 BM.TET2.LSK.2.BAM
- GSM8568410 BM.TET2.LSK.3.BAM
- GSM8568411 BM.TP53.TET2.LSK.1.BAM
- GSM8568412 BM.TP53.TET2.LSK.2.BAM
- GSM8568413 BM.TP53.TET2.LSK.3.BAM
- GSM8568414 BM.TP53.TET2.LSK.4.BAM
- GSM8568415 Spleen.WT.LK.1.BAM
- GSM8568416 Spleen.WT.LK.2.BAM
- GSM8568417 Spleen.WT.LK.3.BAM
- GSM8568418 Spleen.TP53.LK.1.BAM
- GSM8568419 Spleen.TP53.LK.2.BAM
- GSM8568420 Spleen.TP53.LK.3.BAM
- GSM8568421 Spleen.TET2.LK.3.BAM
- GSM8568422 Spleen.TET2.LK.4.BAM
- GSM8568423 Spleen.TET2.LK.7.BAM
- GSM8568424 Spleen.TET2.LK.8.BAM
- GSM8568425 Spleen.TP53.TET2.LK.1.BAM
- GSM8568426 Spleen.TP53.TET2.LK.2.BAM
- GSM8568427 Spleen.TP53.TET2.LK.3.BAM
- GSE285355 Tp53 and Tet2 mutations cooperatively transform GMP (RNA-Seq) 12 samples shares tp53, tet2, cooperatively, mutations, transform, rna-seq
- GSE171815 Loss of BAP1 cooperates with TP53 deficiency to transform a common myelo-erythroid progenitor (RNA-seq - mus musculus) 27 samples shares tp53, transform, rna-seq
- GSE266948 Loss of BAP1 cooperates with TP53 deficiency to transform a common myelo-erythroid progenitor (scRNA-seq - mus musculus) 10 samples shares tp53, transform, rna-seq
- GSE190226 Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability [BGI-RNA-Seq] 21 samples shares tet2, rna-seq
- GSE327454 TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis [RNA-seq] 19 samples shares tet2, rna-seq
- GSE264595 The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia (RNA-Seq) 18 samples shares tp53, rna-seq
- GSE243492 MALAT1 is required for phenotypic consequences of TET2 mutations in myeloid neoplasms. 12 samples shares tet2, mutations
- GSE266580 Ablation of Id1 Reduces Clonal Hematopoiesis, Genomic Instability and Delays Leukemia in Mice with Tet2 Loss of Function [RNA-seq] 12 samples shares tet2, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.