← BioTransfer GEO Dataset Finder
GEO series

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 [scRNA-seq]

GSE279543 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/22 Platform GPL24247
Summary
A critical question in physiology is to understand how tissuesadaptand alter their composition in responsetodietary cues.The mammalian small intestine, avitaldigestive organ thatabsorbs nutrients, is maintainedby rapidly renewing Lgr5+ intestinalstem cells (ISCs) located attheintestinal crypt base. While Lgr5+ ISCs drive intestinal adaptation by altering self-renewing and differentiating divisions inresponse todiverse diets such as high-fat diets and fasting regimens, little is known about howmicronutrients, like amino acids, instruct Lgr5+ ISCfate decisions to control intestinal homeostasis and repair after injury. Here, we demonstrate that cysteine, an essential amino acid, enhances theability of Lgr5+ ISCs to repair intestinal injury.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE279543_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1173219 and SRA study SRP538732. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.