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BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs

GSE279589 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/02/27 Platform GPL20301
Summary
To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate.
Published in
BCR::ABL1-Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B-ALL Cells to Enhancer-Targeting Drugs
Ng HL, Glaser TL, Zhu J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41764406 · doi:10.1002/advs.202517231
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Also filed as BioProject PRJNA1173556 and SRA study SRP538884. Searching any of these in the dataset finder brings you back here.

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