G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × PEO1 B, G4 CT, vs 3 × PEO4 B, G4 CT, vs 3 × PEO1 B, h3k27ac CT, vs 3 × PEO4 B, h3k27ac CT,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cellsGenome biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279641_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1173756 and SRA study SRP538969. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8577353 PEO1 B, G4 CT, Rep1 PEO1 B, G4 CT,
- GSM8577354 PEO1 B, G4 CT, Rep2 PEO1 B, G4 CT,
- GSM8577355 PEO1 B, G4 CT, Rep3 PEO1 B, G4 CT,
- GSM8577356 PEO4 B, G4 CT, Rep1 PEO4 B, G4 CT,
- GSM8577357 PEO4 B, G4 CT, Rep2 PEO4 B, G4 CT,
- GSM8577358 PEO4 B, G4 CT, Rep3 PEO4 B, G4 CT,
- GSM8577359 PEO1 B, h3k27ac CT, Rep1 PEO1 B, h3k27ac CT,
- GSM8577360 PEO1 B, h3k27ac CT, Rep2 PEO1 B, h3k27ac CT,
- GSM8577361 PEO1 B, h3k27ac CT, Rep3 PEO1 B, h3k27ac CT,
- GSM8577362 PEO4 B, h3k27ac CT, Rep1 PEO4 B, h3k27ac CT,
- GSM8577363 PEO4 B, h3k27ac CT, Rep2 PEO4 B, h3k27ac CT,
- GSM8577364 PEO4 B, h3k27ac CT, Rep3 PEO4 B, h3k27ac CT,
- GSE339365 Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19 120 samples shares cut, reprogramming
- GSE229733 Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft-versus-Host disease onset 122 samples shares cut, resistance
- GSE244446 Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13) [ACT-Seq] 32 samples shares cut, promote
- GSE324154 Therapy Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukemia through Reduced EZH2 Activity 22 samples shares cut, promote
- GSE279521 Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia [UMI4C] 13 samples shares cut, promote
- GSE244275 Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13) [4C-Seq] 10 samples shares cut, promote
- GSE308983 Reprogramming lineage features promotes epithelial behavior in carcinoma cells [ChIP-Seq] 23 samples shares reprogramming, promote
- GSE254366 Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated CRC. 36 samples shares reprogramming, resistance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.