GEO series
Interferon-induced immunoproteasomes disturb neuronal metabolism and drive neurodegeneration in multiple sclerosis [RNS_Seq3_Nuclei]
GSE279707
Mus musculus
Expression profiling by high throughput sequencing
20 samples
2025/07/20
GPL21103
Summary
In this study, we investigated the proteasome composition and activity of neurons in CNS inflammation. Therefore, we investigated the multiple sclerosis mouse model and IFNy treated neurons. Thereby, we identified that the immunoproteasome leads to proteasomal dysfunction in neurons with subsequent accumulation of proteins that lead to ferroptosis.
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Paper (PMID 40532699) ↗
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