GEO series
Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion
GSE279754
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/10/14
GPL24247
Summary
Here we uncover that TNF-receptor associated protein-1 (TRAP1) expression in TAMs is markedly reduced in the TME, a process mediated by the TIM4-AMPK signaling pathway. In addition, TRAP1 deficiency leads to increased activity of mitochondrial electron transport chain complexes and an elevated α-ketoglutarate (α-KG) to succinate ratio. The increase in α-KG facilitate JMJD3-mediated histone demethylation, altering genes expression associated with immunosuppressive activation in macrophages.
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Paper (PMID 41162642) ↗
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