Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasionNature immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279754_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1174208 and SRA study SRP539221. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8579672 Ctrl_1A
- GSM8579673 Ctrl_2A
- GSM8579674 Ctrl_3A
- GSM8579675 TCM_1A
- GSM8579676 TCM_2A
- GSM8579677 TCM_3A
- GSM8579678 TRAP1_KO_TCM_1A
- GSM8579679 TRAP1_KO_TCM_2A
- GSM8579680 TRAP1_KO_TCM_3A
- GSM8579681 TRAP1_KO_TCM_4A
- GSM8579682 JMJD3_WT_TCM_1A
- GSM8579683 JMJD3_WT_TCM_2A
- GSM8579684 JMJD3_WT_TCM_3A
- GSM8579685 JMJD3_KO_TCM_1A
- GSM8579686 JMJD3_KO_TCM_2A
- GSM8579687 JMJD3_KO_TCM_3A
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares macrophages, drive
- GSE285794 Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion 12 samples shares macrophages, evasion
- GSE285614 Adipocyte death drives fat redistribution from adipocytes to hepatocytes in steatotic liver disease via S100A8+ macrophages [RNA-seq] 34 samples shares macrophages, drive
- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares mitochondrial, macrophages
- GSE327604 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [RNA-Seq] 12 samples shares mitochondrial, drive
- GSE295742 Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity 12 samples shares mitochondrial, activity
- GSE267546 Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide 12 samples shares macrophages, drive
- GSE290434 A stress response axis in tumor-associated macrophages dictates phenotype heterogeneity and immunotherapy evasion 21 samples shares macrophages, evasion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.