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Elucidating human female genital tract resident DC response to HIV-1 exposure.

GSE279775 Homo sapiens Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/11/08 Platform GPL24676
Summary
The female genital tract (FGT) represents a complex and dynamic environment with specialized immune mechanisms uniquely designed to maintain a delicate balance between protection against invading pathogens and accommodating the unique physiological changes associated with reproductive function. Dendritic cells (DCs) are critical in shaping mucosal immunity against pathogens and maintaining tissue homeostasis. The unique ability of DCs to recognize invading pathogens through pattern recognition receptors (PRRs), and prime naive T cell function, make DCs ideal targets for vaccination and therapeutic strategies against cancers and infections. However, in HIV pathogenesis, DCs are considered a double-edged sword due to their ability to secrete anti-viral proteins and resist viral replication but capture and transfer active viral particles to target CD4+ T cells. Understanding the heterogeneity of DC populations in the FGT, along with their unique contribution to HIV pathogenesis is key for targeted interventions.
Published in
Human genital dendritic cell heterogeneity confers differential rapid response to HIV-1 exposure
Parthasarathy S, Moreno de Lara L, Carrillo-Salinas FJ et al. · Frontiers in immunology 2024 · PMID 39524443 · doi:10.3389/fimmu.2024.1472656
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Direct links to NCBI, no account and no request form: the whole study as GSE279775_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1174233 and SRA study SRP539246. Searching any of these in the dataset finder brings you back here.

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