Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 7 × I_WT vs 5 × I_CREGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferationNature immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279898_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1175312 and SRA study SRP539656. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8582748 I_WT_1 I_WT
- GSM8582749 I_WT_2 I_WT
- GSM8582750 I_WT_3 I_WT
- GSM8582751 I_WT_4 I_WT
- GSM8582752 I_WT_5 I_WT
- GSM8582753 I_WT_6 I_WT
- GSM8582754 I_WT_7 I_WT
- GSM8582755 I_CRE_8 I_CRE
- GSM8582756 I_CRE_9 I_CRE
- GSM8582757 I_CRE_10 I_CRE
- GSM8582758 I_CRE_11 I_CRE
- GSM8582759 I_CRE_12 I_CRE
- GSE301976 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2] 12 samples shares il-25, ilc2
- GSE301975 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1] 8 samples shares il-25, ilc2
- GSE301999 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq] 4 samples shares il-25, ilc2
- GSE301998 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq] 36 samples shares il-25, ilc2
- GSE298909 Tim-3 Agonist Restrains ILC2 Function and Attenuates Airway Hyperreactivity via NLK Pathway 6 samples shares ilc2, restrains
- GSE313261 Global transcriptome analysis of IL-33, IL-25, IL-13, TSLP, IL-4, and IL-9 overexpression in mouse spleen 49 samples shares il-25
- GSE230599 Cross-talk between ILC2 and Gata3high Treg locally constrains adaptive type 2 immunity 41 samples shares ilc2
- GSE326762 Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression - RNA-Seq 35 samples shares ilc2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.