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Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

GSE279917 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/14 Platform GPL18573
Summary
This study evaluates mechanisms of glycaemic stress underpinning cardiovascular risk in diabetes. Using in vitro and in vivo models, we demonstrate that glycaemic variability rather than hyperglycaemia alone is a dominant risk factor for heart muscle dysfunction and myocardial injury sensitivity in diabetes. These findings provide new preclinical models for mechanistic and drug discovery studies and inform strategies for managing cardiovascular outcomes in patients with diabetes.
Published in
Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes
Cao Y, Redd MA, Outhwaite JE et al. · Nature communications 2026 · PMID 42000722 · doi:10.1038/s41467-026-71809-x
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Also filed as BioProject PRJNA1175386 and SRA study SRP539689. Searching any of these in the dataset finder brings you back here.

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